BMC Bioinformatics–Novel deep learning model for more accurate prediction of drug-drug interaction effects

对许多疾病的最有效疗法通常是药物组合的结果。在癌症，高血压，哮喘和艾滋病病例中，给药多个分子会导致药物效率的提高，并降低靶细胞的毒性和耐药性。然而，不同的分子也可能以有害的方式相互作用。因此，了解患者是否处方多种药物的重要性。已经进行了不同的研究，试图预见体内可能的药物相互作用。体内testing is often limiting because it requires a long time to screen different compounds.In silico相反，研究被证明更强大。

通常，计算方法考虑了分子的已知特征，例如结构，目标和副作用。李本月发表的一篇文章等。inBMC Bioinformatics显示了formulation of a new deep learning model to predict drug-drug interaction, that takes into consideration three concepts: target similarity profiles (TSP), Gene Ontology (GO) term similarity profiles (GO term gives information about the gene function, where it acts inside the cell and in which biological process it is involved) and Structural similarity profiles (SSP). Three similarity profiles are traced for any given drug pair. These are then joined together to provide an estimation of the level of interaction between the two molecules. This approach allowed the authors to identify, with the same or greater accuracy, drug-drug interactions that were characterized using different methodologies.

BMC Cancer–年轻患者肺腺癌的分子特征

Incidence of lung cancer in the population increases with age and it is rarely diagnosed in young people. It has been shown that clinic-pathological features of lung cancer in younger and older patients are not the same. However, previous research in the field has not shown conclusive results and still remains elusive.

In this study carried by researchers of Zhejiang University (China), specimens of cancer cells from 89 young patients (35 years old or younger) with adenocarcinoma were analyzed. The majority of patients were women and only 1 in 10 were smokers.

Prognosis was also seen to vary according to the mutations involved in cancer onset.

Next-generation sequencing was used to identify the mutation of 59 cancer-related genes. The most frequently mutated genes identified were ERBB2 (Receptor tyrosine-protein kinase erbB-2) and EGFR (epidermal growth factor receptor). Fusion of ALK (Anaplastic lymphoma kinase) and ROS1 (receptor tyrosine kinase) genes was also characterized as responsible for oncogenesis. No significant correlation was seen between the mutations (or fusion) identified, the gender or the smoking habit of the patient. Overall, a prevalence of ERBB2 mutations was characterized in well/moderately differentiated tumors, while EGFR mutations and ALK fusions were identified in moderately/poorly differentiated tumors. Prognosis was also seen to vary according to the mutations involved in cancer onset.

BMC怀孕和分娩–为什么农村妇女不使用初级卫生中心进行怀孕护理：尼日利亚定性研究的证据

Maternal mortality rates in developing countries are still unacceptable and although policies were made by local governments, around 830 women still die every day because of pregnancy or childbirth complications. 99% of these deaths happen in developing countries and they are, in most cases, preventable.

尼日利亚是孕产妇死亡率最高的国家之一，在农村地区达到高峰。2014年，政府启动了一项计划，为弱势群体提供初级卫生保健。尽管做出了努力，但农村孕妇并未使用这项服务，也没有在怀孕和分娩期间获得医疗支持。

Women also reveal that often the quality of care is not adequate

A qualitative study inBMC怀孕和分娩调查了不使用提供初级卫生保健设施的妇女危险选择的原因。通过焦点小组的讨论使作者能够确定这种趋势背后的一些主要主题。参与者强调了到达卫生中心的困难，因为铺好的道路不存在，并且使用可用的不良道路是有风险的。获得运输平均值和到设施的距离的困难也被确定为重要的障碍。

此外，参与者表示，这些诊所并非始终开放，并在那里旅行，并发现他们拒绝他们在其他场合使用医疗机构。

令人惊讶的是，女性还透露，护理质量通常不够。没有药物来减轻疼痛，等待时间很长，环境不友好，医疗保健专业人员不支持或胜任。除了相信传统的医学和神圣干预措施与卫生中心的工作人员一样多，还促使妇女避免寻求这种专业帮助。最后，参与者还提到，护理成本是任意的，这些设施通常要求患者从他们那里购买消耗品，这可能很昂贵。

考虑到所有因素，这项研究表明，政府对孕产妇死亡的解决方案仍然不足。设施可及性和护理质量的改善将激发妇女在怀孕期间依靠专业帮助。但是，仍然需要朝这个方向完成很多工作。

BMC Palliative care–Designing and developing a co-produced theoretical and evidence-based online support for family caregivers of people with dementia at the end of life

大多数患有痴呆症的人都生活在社区中，但大多受到家人或朋友的照顾。照顾受这种情况影响的爱人可能非常具有挑战性，尤其是随着疾病的发展和生命的终结。

伦敦大学学院的研究人员设计和开发了一个在线姑息治疗支持网站，针对生命末期痴呆症患者的护理人员的真正问题。照顾痴呆症亲戚的负面影响包括抑郁症，身体健康不良和生活质量差。研究人员很肯定，该工具将帮助护理人员发挥作用，并帮助改善其整体福祉。

BMC肌肉骨骼疾病–Corticosteroid injection for plantar heel pain: a systematic review and meta-analysis

由足底筋膜炎引起的脚跟疼痛可能是坚持的，并且会损害日常活动，例如步行或跑步。大约7％的人口患有这种情况。在许多情况下，休息或变化的习惯足以随着时间的流逝缓解症状。但是，如果症状持续存在，则有必要诉诸不同方法，例如物理疗法或皮质类固醇注射，因为它们有助于减轻疼痛和炎症。目前尚不清楚为什么要经常开处方皮质类固醇，因为仍然缺乏其作用方式的证据。

皮质类固醇注射将充当安慰剂

发表在BMC肌肉骨骼疾病gathered together trials and studies on the topic and elucidated in which occasions injections are effective and when they are wrongly prescribed. The review showed that Corticosteroid injections prove to be effective in the short term, in comparison to autologous blood injection, orthotics or physiotherapy. However, in the long term, platelet-rich plasma or dry needling seem to have better results. Therefore, the Corticosteroid injections would act as a placebo. Remarkably, the effect of the steroid injections seems, therefore, minimal. Further clinical trials could provide us with a better understanding of the most effective ways of treatment for this condition.