Highlights of the BMC Series – April 2021

Responding to a pandemic - Research integrity, misconduct and consequences - Equity in clinical trial registration - Nitrogen-fixing legumes and reforestation - Vitamin D and magnesium a successful treatment for children with ADHD?

BMC心理学 - 如何应对大流行:保持冷静并待在家里?


In an interesting analysis, researchers from Technical University in Munich and the University of Cambridge investigated the difference in the response to COVID-19 pandemic between Germany and UK residents. Their findings (published now inBMC心理学)突出一个明显的差异与英国参与者相比,很快就会结束。

总的来说,这两个种群显示sy的增加mptoms of mental illnesses, most prominently depression and anxieties, induced or worsened by the pandemic. This alarming increase calls for a better public awareness of mental health and mental illness as well as better access to help in both countries.

The comparison between Germany and the UK is particularly interesting because both countries are economically and culturally very similar. However, the initial response to the pandemic differed between both countries, with Germany locking down considerably earlier than the UK, which has been shown to have impacted number of deaths.


BMC医学伦理 - 研究完整性,不当行为和后果


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在最近发表的一项研究中BMC Medical Ethics,,,,researchers from Hungary, Ireland, the UK and Norway collected and analysed data concerning cases of research misconduct available in scientific journals. Interestingly, the field of natural sciences (41.5%) was found to have the most cases in relation to number of publications in the field, followed by health and medical sciences (25.1%) and engineering (22%).

The most prevalent misconduct category was fabrication and falsification of data with non-adherence to pertinent laws such as informed consent and ethics approval ranking second. Additionally, the researchers assessed the consequences for research misconduct finding paper retraction (45.4%) and exclusion from funding applications (35.5%) to be the most common sanctions.

The authors of this study further criticise that retraction notices often do not contain sufficient detail, thus impeding transparency of the retraction process. Comprehensive analyses such as this study guide the research community in finding ways to prevent misconduct and upholding research integrity standards.

BMC医学研究方法 - 临床试验注册中的公平性 - 为什么较高疾病患病率的地方尚未与试验地点保持一致?

Clinical trials aimed to investigate treatment options for specific illnesses often do not recruit from populations with high prevalence of the respective disease.

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他们的定性研究结果现已发表在BMC Medical Research Methodologyrevealing that the main factors in site selection for CIs is to ensure a successful trial procedure and the risk associated with choosing less research-active sites. Mainly, CIs are conscious of potential issues with patient recruitment and retention and are concerned with the effect a less successful trial might have on their reputation and future funding opportunities. This often leads to CIs selecting sites where they have a personal contact or with which they have collaborated in the past, thereby perpetuating this system of inequity.


BMC Research Notes – Reforesting our planet using nitrogen-fixing legumes



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Here, Brazilian researchers present data on the use of different legume plants in restoration efforts, published now inBMC Research Notes。固氮豆类是恢复土壤并为第二代植物提供良好基础的有用工具,但是该过程通常很慢。

By measuring biomass growth of reforestation blocks treated with different fertilisation regimens, the researchers were able to show a fundamental role for additional fertilisation during the early stages of plantation development.

These findings will be important for policymakers in setting up strategies to mitigate global warming and retrieve carbon from our atmosphere using natural fixation by plants.

BMC儿科 - 维生素D和镁补充是为ADHD儿童的成功治疗吗?

Problem child and desperate mother at psychological centre.
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在一项发表的研究中BMC儿科Hemamy and colleagues present data from a randomised, placebo-controlled trial investigating the effect of vitamin D/Mg supplementation on Iranian children with ADHD. Interestingly, the researchers find significant improvement in several behavioural variables including emotional and peer problems, where children in the treatment group scored significantly better than those receiving a placebo.

This research lays the groundwork for bigger clinical trials investigating the impact of vitamin D and magnesium on the behaviour of children with ADHD as well as the underlying physiological mechanism leading to potentially new treatment recommendations.