在短短的几个月中，SARS-COV-2冠状病毒在世界各地蔓延。该病毒会感染呼吸道（呼吸）系统，引起发烧和连续咳嗽，并可能发育为肺炎。
这re is currently no vaccine against the virus or approved specific treatment for COVID-19 (the disease caused by the virus), althoughremdesivirhas been authorized for emergency use by the US FDA pending formal approval.
迫切需要进行临床试验，以确定COVID-19的治疗和疫苗的有效性。在我们的博客中临床试验日2020 we look at a selection of the ongoing COVID-19-related trials that have been registered at theISRCTN registry今年到目前为止。
毒品
这World Health Organization (WHO) has organized the international团结trial to compare untested treatments for COVID-19 with each other. The study treatments include drugs that are currently used to treat other conditions such as the antivirals remdesivir and lopinavir plus ritonavir, the antimalarials chloroquine and hydroxychloroquine, and interferon-beta, which is used to treat multiple sclerosis.
在英国RECOVERYtrial is assessing a similar selection of possible treatments at many hospitals. At the time of writing RECOVERY is the世界上最大的审判用于治疗Covid-19患者的药物。像团结一样，恢复具有自适应试验设计，这意味着随着证据的出现，正在将新的治疗方法添加到试验中。
Currently the treatments being tested include lopinavir plus ritonavir and hydroxychloroquine as mentioned above, as well as corticosteroids (typically used to reduce inflammation), azithromycin (a commonly used antibiotic), and tocilizumab (a treatment for rheumatoid arthritis).
羟氯喹也正在分别测试原则研究在英国全科医生。本研究specifically recruiting people who are at a higher risk from infection with the virus, such as people aged 65 and over, or those known to have one of the following conditions: a weakened immune system, heart disease, asthma or lung disease, diabetes, mild hepatic impairment, or stroke.
疫苗
疫苗是控制暴发的最具成本效益的方式，国际社会已加大了为与Covid-19的开发疫苗的努力。这COV001andCOV002studies based in Oxford (UK) are testing a new vaccine on healthy volunteers to see if they can be protected from COVID-19. They will also provide valuable information on the safety of the vaccine and its ability to generate good immune responses against the virus.
呼吸支持
新冠肺炎has placed a huge burden on intensive care units as many patients experience breathing problems and require a ventilator. The RECOVERY Respiratory Support (恢复RS）研究是测试旨在防止人们进行呼吸机的测试治疗方法。
将患者随机分配以通过紧身的面膜（连续气道压力[CPAP]）或通过机器（高流量鼻氧[HFNO]）或正常的氧气面膜吹向鼻子。CPAP和HFNO都在NHS中常规使用了其他条件。
Testing
进行Covid-19的快速床头测试可能使医生能够更快地识别受感染的患者，并阻止病毒在医院中传播。它还可以识别那些没有更早感染的人，从而使他们可以从隔离室中取出并更快地送回家，从而减轻了医疗保健系统的压力。目的CoV-19POC研究是为了找出对Covid-19的新快速测试是否导致早期决策并更好地护理患者。
Healthcare workers
前线医疗保健工人，例如急诊科的人员，由于与可能患有该病毒的患者的密切接触，患有Covid-19的高风险。这HEROs在加拿大的五家医院进行的研究旨在找出在接触患者之前和暴露期间服用羟氯喹是否会降低其Covid-19-19感染的风险。
这COVVA西班牙的研究正在看the effects on healthcare workers of wearingpersonal protective equipment (PPE)，例如N95呼吸器和FFP2面具，调查是否可以改善其工作条件。在隔离区工作后，询问医护人员的存在，例如头痛和皮肤病变。
Impact on other conditions
这覆盖study is an international study aiming to collect information on how the COVID-19 pandemic is affecting the medical care of patients with artery and vein (血管）条件。这是一个重要的问题，因为患有此类健康问题的患者通常还有许多其他健康问题和/或老年人。这使他们更有可能发展威胁生命的并发症。
这ukoss: Pandemic COVID-19 in pregnancy study is collecting information about all pregnant women admitted to hospital with COVID-19 in the UKto investigate the effects of the infection and treatments on the mother and baby。
Stressful major events such as a global pandemic can disrupt sleep. However, by intervening early, this may be stopped from becoming a long-term problem.这睡眠covid-19研究正在以睡眠教育的形式测试一种早期的在线治疗，因为那些最近报告睡眠不佳的人。
这stay-at-home message
这ISRCTN registry supports global research on COVID-19 by giving priority to prompt registration and reporting of COVID-19-related studies. All registered studies are made available worldwide through the WHO’sInternational Clinical Trials Registry Platform（（ICTRP).
To find out more about what ICTRP and its network of registries are doing to make information on clinical research accessible during the pandemic, take a look atthis blog来自谁和this blogby the ISRCTN Database Manager.
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