BMC基因组数据:De novo genome assembly and analysis unveil biosynthetic and metabolic potentials of Pseudomonas fragi A13BB

Pseudomonas fragi作为研究的一部分，A13BB从根际收集的土壤样品中鉴定出新的抗生素产生的细菌菌株已被测序用于抗生素产生的基因簇，并已发表为第一数据NoteinBMC基因组数据。促进植物生长的根瘤菌（PGPR）是根际的组成部分之一，它们通过增强养分，无机元素的摄取或增加对重金属，高盐浓度，植物病毒等的耐药性来促进植物生长。

Two β-lactone secondary metabolite biosynthetic gene clusters (smBGC) known for their antibiotic, antiobesity and anticancer properties, were identified and demonstrated low homology (20%) to known smBGCs. A siderophore (a small compound secreted usually to transfer iron across cell membranes) smBGC was identified even thoughP. fragiis considered a non-siderophore producing member of the genusPseudomonas.

BMC Nutrition:在2000年至2015年之间，向太平洋岛屿国家的进口饮料进口是否增加？

Thisstudywas intended to identify trends in the variety and amount of imported sweetened beverages (SB) to Pacific Island countries (and the impact of the SB taxes on imports in Fiji and Tonga). A major cause of death and sickness in these countries is nutrition-related chronic diseases.

The authors found there was an increase in SB imports into pacific island countries between these dates which needs to be considered for health implications by both exporting and importing countries as this has a detrimental impact on diet and self-sufficiency. Diet high in processed foods is well known to have an impact on health. There was a statistically significant increase in SB imports to Tonga but too little data for assessment of taxes.

BMC精神病学:对Covid-19期间NHS心理保健工作者的经历的定性研究

Thirty five members of NHS secondary mental health services (England) undertook an interview based study and were found to face difficulties that impacted significantly on their well-being during the pandemic.

响应于SARS-COV-19引起的大流行的封锁对所有医疗保健工作者产生了影响，但对精神保健工作者的限制已经不足。受访者的生活质量受到他们在受约束和潜在危险情况下提供护理并使患者失去疾病的挑战的影响。承担其他任务为患者提供更好的服务导致额外的压力。据报道，悲伤，无助，孤立，痛苦和倦怠的感觉都被报道了。对大流行的反应意味着，随着服务用户需求的增加，服务必须同时迅速适应大型事件模式。暴露于此事件后，道德伤害导致一些。

Thisstudyhas pointed to areas where additional support could be targeted. One Implication is loss of staff but this has not been explicitly stated.

BMC Medical Ethics:Cultures and cures: neurodiversity and brain organoids

现在可以将患有自闭症谱系障碍（ASD）的供体的细胞生长到脑器官中，由此产生的研究使我们对ASD病因的理解开放。脑器官允许对遗传，发育和其他因素进行探索，从而使其他形式的研究与众不同。研究人员经常将残疾医学模型纳入ASD研究。

神经多样性运动可能不同意ASD中脑研究的方法和目标，因为发展障碍运动和范式将自闭症理解为人类多样性的一种形式，并主张基于社会，态度和环境障碍的模型，而不是任何缺陷。

Theauthors给出三个建议，以最大程度地减少任何冲突，并实现对ASD的脑器官研究的更全面，包容的方法。

1 - 在科学过程和研究沟通中，神经多样性的个人应作为共同创造者。

2 -临床医生和neurodiverse社区have open and respectful communication.

3 - 应实现疾病，障碍，残疾，行为和人的持续重新概念化。

Researchers are advised to be careful not to combine disease with impairment or disability and also consider how best to communicate their ideas with respect and care.

BMC Endocrine Disorders:维生素和矿物质补充对妊娠糖尿病女性的影响

Gestational diabetes mellitus (GDM) is defined as impaired glucose tolerance with onset or first recognized during pregnancy. It is fairly prevalent with a figure of 15-20% reported globally. Hyperglycaemia is associated with adverse outcomes for mother and baby.

Vitamin and mineral supplementation such as vitamin D, vitamin E, magnesium, and selenium may regulate glucose metabolism and have beneficial roles in anti-inflammatory and anti-oxidative stress.; does it help in GDM? The effects of vitamin and mineral supplementation on women with GDM have not been well established but this荟萃分析希望纠正这一点。

作者的发现是维生素和矿物质补充剂；镁，锌，硒，钙，维生素D和E（单独或组合），通过降低血清空腹血浆葡萄糖，胰岛素和其他水平以及增加总抗氧化剂，可以显着改善GDM女性的血糖控制，炎症和氧化应激减少和氧化应激容量水平。