2型糖尿病是全球公共卫生问题。后果 - 四肢失去，失明，长期对胰岛素注射的依赖 - 可能会极大地破坏生活质量，并且对医疗服务的财务影响可能很大。
Meanwhile, despite global and national initiatives to reduce air pollution, exposure is a constant in day to day life, particularly in highly urbanized areas. There has been some investigation into the links between fine particles and increased risk of cardiovascular disease, but could ultrafine particles, those less than 100nm in size, pose a threat to the cardiovascular health in diabetes patients?
本周发表的两篇论文粒子和纤维毒理学， 一来自中国的作者还有一个在德国工作的团队，这可能是这种情况。两支球队都使用心电图来评估糖尿病患者或葡萄糖耐受性受损（糖尿病前）的心脏功能，以不同的时间暴露于空气污染物中。两篇论文的发现都表明，这种暴露与这些组中心血管疾病的风险增加有关。作者下面解释了其研究背后的动机和方法。
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Type 2 diabetes affects 114 million Chinese people and is the leading cause of blindness, lower extremity amputations, and hypertension, as well as a major cause of end-stage renal disease and cardiovascular disease.
一个recent World Health Organization publicationreported that fine particulate matter (PM2.5）代表4Th在亚洲，由残疾调整的生活年的主要原因。下午2.5exposure contributes to insulin resistance and high blood pressure, but its role in perturbing glucose and blood pressure control in real world clinical settings has not been investigated.
由于全世界和中国糖尿病的患病率不断增长，并且与心血管疾病的风险增加有关，我们旨在确定在暴露于环境颗粒的患者中，糖尿病或糖尿病受损是否可能改变心血管结局。
在our study，，，，we followed a group of pre-diabetic and diabetic subjects under a chronic disease surveillance system managed by local center for disease control and surveillance in Shanghai. We found that with increasing concentration of ambient particles, there was a significant effect on heart function.
最大的差异是响应颗粒的最小尺寸（小于100 nm）的响应，并且直径在100-200 nm之间的颗粒较小的差异。与交通相关污染物BC，NO2和CO以及燃烧污染物SO2的暴露增加也与心电图参数降低显着相关。
Diabetes and gender appear to have a significant effect on the autonomic dysfunction associated with acute exposure to ultrafine particles and traffic pollution.我们的结果支持以下假设：糖尿病或葡萄糖耐受性受损可能导致心脏不规则功能，以应对交通污染的暴露。
这强调了将空气污染作为中国的公共卫生重点的必要
来自德国奥格斯堡：安妮特·彼得斯博士和亚历山德拉·施耐德博士
在our study，我们能够表明，升高的环境颗粒数浓度与2型糖尿病或糖尿病前糖尿病患者的心跳立即变化有关。该关联独立于其他因素，例如天气或体育锻炼。
The observed associations with exposures were attributable to particles from outdoors as well as indoors, such as exposure to tobacco smoke. We decided to measure the total number of particles using a concentration particle counter. Based on extensive measurements, we knew that the total number count is dominated by particles below 100 nm, called ultrafine particles. Meanwhile, we used electrocardiogram readings to assess cardiac function, as they can measure changes continuously.
糖尿病患者在高空气污染暴露时特别容易患心血管疾病。但是，为了控制可能减轻环境空气污染影响的药物的作用，我们包括了一群健康的个体，这些人具有早期的葡萄糖代谢迹象。我们看不到研究的两个亚组之间的显着差异。
Overall,研究证明个人活动还导致与燃烧相关的颗粒外，除了细颗粒物。在相对干净的空气环境中观察到这些结果（低于目前的欧洲标准颗粒标准）。
The results indicate that exposure to particles during times spent in traffic may impair cardiac function and thereby contribute to an elevated risk of triggering a heart attack. This suggests there is a need for further measures to protect the public from short-term exposure to ultrafine particles in urban environments, in addition to the currently regulated fine particles.
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While regulation of fine particulate matter has been introduced, the risk of ultrafine particles is less well known. The immediacy of the risk of air pollution to those with type 2 diabetes, is exemplified by these two studies which, although conducted in very different countries, have resulted in a similar call for public health intervention.
我们的生物eff庞大的研究经验ects of various particles like silicon dioxide, asbestos, mica, coal, manganese dioxide on pulmonary system, all are fibrogenic and they may produce fibrosis or other pulmonary disorders. Naturally, this will hamer the physiological pathwat of clearance and pathological pathway of clearance leading to more adverse effective pressure on all vital organs. Moreover, ultrafine particles and nanoparticles by lymphohematogenous spread can reach to all vital organs of the body including heart and brain in exposed people. The compronmised population llike diabetic person will have more problems without any doubt.