BMC系列的亮点:2014年5月

古老的MOA中的无翼•性别之战开始于输卵管•未发现的厌食症衣原体•单分子跟踪9/11•3D打印后的健康需求改善了胚胎筛查

BMCWORDLE进化:古代莫阿的无翼

回归进化的肢体损失在本质上是普遍的,例如鲸鱼,蛇和一些sal。在级别中也发现了前肢的损失:包括古代巨型MOA在内的一群鸟类,这是新西兰特有的物种,在15世纪被人类灭绝。TBX5是大多数动物前肢发展所必需的关键基因之一。在这里,Huynen及其同事重建,构建和表征TBX5,以研究巨型MOA中无翅的分子基础。他们的结果表明,TBX5在MOA的残留前肢腰带中必须发挥重要作用,但正是其他基因的变化导致MOA失去了翅膀。在我们的上了解更多有关这些巨型无飞行鸟的信息博客

基因组学:性别之战开始于输卵管

哺乳动物中后代的性别分配只是机会问题吗?在这里,Almiñana及其同事研究了一个替代假设,即产卵可以识别X和Y精子,从而偏向后代性别比。通过检查精子是否在雌性猪的产卵中引起不同的转录组反应来测试。微阵列分析的结果表明,与X含X染色体的精子相比,在存在Y染色体的精子的情况下,在存在Y染色体的精子的情况下,卵形的501次转录本持续改变。这些转录本包含信号转导和免疫相关基因的高度表示。研究人员得出的结论是,输卵管是一种生物传感器,可以响应X和Y精子来微调其生理和基因表达。

传染性疾病:未发现的厌食症衣原体

Chlamydia can cause anorectal infections in women as well as infection of the urogenital tract. Current recommendations include restricting testing to people in high-risk groups that report anal sexual behaviour or have anal symptoms. Here, 663 women attending an STI-clinic were offered routine testing for anorectal and urogenital chlamydia. Results revealed an alarmingly high number of women with anorectal chlamydia; of all women with urogenital chlamydia, 71% had co-occurring anorectal chlamydia. Two thirds of the anorectal chlamydia infections were being missed. Van Liere and colleagues conclude that current selective testing on indication of symptoms and sexual history is not an appropriate control strategy for anorectal chlamydia.

本月的图像:

BMC系列突出显示图像2使用单分子跟踪对两个粒子轨迹进行仿真。从 ”TRACTART:用于单分子跟踪数据分析的用户友好界面,并应用于云母支持的脂质双层中的复杂扩散” Matysik和Kraut BMC Research Notes 2014,7:274

公共卫生:9/11之后的健康需求

对未满足的精神卫生保健need (UMHCN) of people exposed to the 9/11 terrorist attacks in New York. Ghuman and colleagues report data from 9,803 people who had Post Traumatic Stress Disorder or Depression 10-11 years after being exposed to the disaster. Just over one third reported a UMHCN, occurring due to a range of attitudinal, cost and access barriers. People who had more severe and disabling conditions, who lacked health insurance and who had low levels of social support were most vulnerable.

生物技术:3D printing improves embryo screening

尽管斑马鱼是整个生物体筛查应用的主要脊椎动物模型系统,但缺乏在微滴定板中斑马鱼胚胎的一致分配和定位,从而阻碍了详细的形态或细胞表型的评分。Wittbrodt及其同事在这里引入了一种经济有效的方法,用于使用桌面3D打印机生产兼容斑马鱼的96孔板兼容斑马。这种新方法很容易再现,并且可以轻松共享数字3D模型,从而改善对开发工具的访问。

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