BMC Infectious Diseases–Impact of delayed processing of positive blood cultures on organism detection: a prospective multi-centre study

许多医疗保健服务没有资源或能力来诊断血液感染的阳性血液样本。结果，诊断实验室服务的集中化变得流行。“集中化”描述了建立一个“中央”实验室，同时关闭或降级外围或较小的实验室。为了更好地利用医疗保健资源并节省资金，血液样本越来越多地运到中心地点进行处理。在一些低收入和中等收入国家中，缺乏必要的基础设施和资源可能意味着集中化是唯一可行的选择。

然而，在将阳性血液样本的亚文化延迟到将病原体运送到中央位置时的诊断产量的影响仍然相对未知。在BMC Infectious Diseases，研究人员发现，延迟亚文化长达一周的延迟不会影响几乎所有已研究的病原体的诊断产量，包括Streptococcus pneumoniae。但是，研究人员证明储存温度可能会影响生存能力，尤其是在热带环境中。该研究提供了有用的数据，可以在设置新的诊断微生物学服务时考虑。

BMC Pediatrics–物理治疗对早产儿骨重塑的影响：多中心随机对照临床试验

According to the World Health Organisation, an estimated 15 million babies are born preterm every year before 37 weeks of pregnancy are completed. These premature babies have a much higher risk of osteopenia. This condition leads to reduced bone mineral density and subsequent disease due to multiple prenatal and postnatal factors that impair bone remodelling.

Bone remodelling is essential for normal growth and development. Osteoclasts remove old bone while osteoblasts lay new. Normally, these two cell types work in balance, but if the rate of bone resorption outpaces new bone formation, the skeleton can become weak.

Physical activities that exert mechanical stress on the bones stimulate bone growth. InBMC Pediatrics, researchers performed a randomised controlled clinical trial to investigate the effect of three different physiotherapeutic methods on bone remodelling in preterm infants. The study found that reflex locomotion therapy (RLT) increased levels of bone formation biomarkers and the height of preterm infants. These results suggest that RLT positively affects bone formation and growth, which may help prevent and treat osteopenia in this population.

BMC Veterinary Research–The impact of the COVID-19 pandemic on a cohort of Labrador retrievers in England

How did COVID-19 pandemic restrictions affect the lifestyle and health of our dogs? To help answer this question, researchers from the University of Edinburgh analysed data from over 4000 Labrador owners in England between March and July 2020.

研究发现，在此期间，拉布拉多人访问兽医的频率较低，并且不太可能被保险。这一发现表明，狗可能没有得到通常的兽医护理水平。此外，在锁定期间，拉布拉多疫苗的疫苗接种次数也减少了 - 这一发现对于促使业主检查狗的疫苗接种病史非常有价值。

However, positives also accompanied pandemic restrictions. For example, Labradors enjoyed increased exercise, were more likely to be wormed and were less likely to be given treats by their owners. Labrador owners also reported less coughing by their dogs. This observation led to the researchers speculating that lockdown decreased the spread of infectious diseases like kennel cough due to a reduction in dogs’ social interactions.

BMC怀孕和分娩–Associations between COVID-19 lockdown and post-lockdown on the mental health of pregnant women, postpartum women and their partners from the Queensland family cohort prospective study

Covid-19-19-大流行限制如何影响孕妇，产后妇女及其伴侣的心理健康？在BMC怀孕和分娩，研究人员使用了一项正在进行的人生妊娠研究中的数据，称为澳大利亚澳大利亚母校母亲医院的昆士兰州家庭队列，以帮助回答这个问题。

孕妇及其伴侣在妊娠24周之前被前瞻性地招募了这项研究。参与研究的454个家庭随后在24周妊娠和产后6周完成了与心理健康和一般福祉有关的问卷。在（2018年8月2日至2020年8月至2020年8月至2020年）和第一次锁定结束后（2020年9月至2020年）之前招募了家庭。

有趣的是，锁定并没有对澳大利亚布里斯班评估人群的心理健康产生负面影响。相反，相对于covid-19的妇女，在锁定期间，妇女在妇女中，孕妇或产后妇女的几率远远超过了一半。此外，相对于19岁前的水平，怀孕和产后妇女的锁骨后妇女的几率降低了70％以上。

This manuscript is part of a Collection of articles focusing on research about maternal mental health and mood during the perinatal period. To find out more, visit:https://www.biomedcentral.com/collections/mmh

BMC Pulmonary Medicine–Prediction of high-flow nasal cannula outcomes at the early phase using the modified respiratory rate oxygenation index

High-flow nasal cannula oxygen therapy (HFNC) provides respiratory support for patients with acute hypoxemia respiratory failure (AHRF) – one of the most common causes of critical illness. However, in cases of HFNC failure, progressing treatment to mechanical ventilation is required. Mechanical ventilation delay is associated with increased mortality risk. InBMC Pulmonary Medicine, researchers reviewed the records of 75 patients with AHRF treated with HFNC to identify early predictors of HFNC success to avoid mechanical ventilation delay and reduce mortality risk. The study finds that two hours after HFNC initiation, a modified respiratory rate oxygenation index (PaO2/FiO2/RR) of less than 7.1 predicts success with HFNC therapy with 100% specificity.