随着糖尿病每年的糖尿病为88亿英镑，糖尿病的成本令人惊叹，因此发现有效措施以防止2型糖尿病至关重要。生活方式计划可以充当有效的预防方法，但决策者面临决定提供哪种类型的决定。密集计划非常有效但昂贵，而低强度程序则较低，但效果也较低。New research published inBMC Medicineexplores this issue by using an economic model to weigh up the options.
During the last 30 years, over 15 million people have received AZT: an antiretroviral used to prevent HIV/AIDS. While it has now been replaced with other drugs in high income countries, it is still used widely in low-to-middle-income countries; this poses issues due to difficulties in detecting resistance to the drug and the side effects it carries. In this blog, author of a paper published inInfectious Disease of Poverty, Eric J. Arts, discusses his career long connection to AZT and the issues with AZT-based treatments in sub-Saharan Africa.
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Tyrosinemia type 1 (TYR1) is an autosomal recessive disorder and sadly without treatment, death in childhood is common. Screening newborns allows for earlier identification of TYR1 but there is uncertainty over the accuracy of the test. In this blog we talk to Sian Taylor-Phillips and Chris Stinton, authors of areview published inOrphanet Journal of Rare Diseasesexamining the accuracy TYR1 screening.
‘Big data’ in clinical trials could have the potential to transform real-world evidence in medicine and healthcare. A newreview published today in试验reflects on the promises, barriers, and implications of this and here, co-authors Lars Hemkens and Kimberly Mc Cord discuss some of the issues and what’s next for clarifying uncertainties.
新年带来new series forBlood Cancer Journal, an open-access journal published by Springer Nature. January 2018 sees the launch of a new article type called ‘Current Treatment Algorithms’. In this blog, Dr Ayalew Tefferi and Dr S. Vincent Rajkumar introduce the concept of this new article type and discuss its relevance in the vast field of hematological cancers.
Simulated scenarios are a vital component in the training of health professionals. Debriefing is seen as a vital part of this learning process, but do students also learn as they engage in scenario-based simulations?Research recently published in模拟的进步seems to suggest that they do.
Despite the increasing effectiveness of breast cancer treatments over the last 50 years, tumors often become resistent to the drugs used. While drug combinations could be part of the solution to this problem, their development is very challenging. In this blog post Jorge Zanudo explains how it is possible tocombine physical and mathemathical models with clinical and biological datato determine which drug combinations would be most effective in breast cancer therapy.
Huntington’s disease is a rare, inherited neurodegenerative disorder that progressively impairs motor and cognitive functions. It was previously thought that exercise might act as a stressor, accelerating disease progression; but now increased knowledge of the underlying mechanisms of the disease has led tonew researchsuggesting that endurance exercise may actually have therapeutic potential for rare diseases like Huntington’s.