Preventive chemotherapy (deworming) has a pivotal role in control of certain neglected tropical diseases (NTDs) such as schistosomiasis and soil-transmitted helminthiasis (STH), as a short-term, rapid impact intervention. As these two diseases are strongly associated with poverty, people frequently get re-infected after treatment from their local environment since they have insufficient access to safe water sources or adequate sanitation and hygiene.

为了产生更持久的健康影响，需要通过其他干预措施（例如水，卫生和卫生（WASH）方法）来增强预防性化疗。

为了产生更持久的健康影响，需要通过其他干预措施（例如水，卫生和卫生（WASH）方法）来增强预防性化疗。

最近的国际会议（COR-NTD，STH＆SCISTOSOMIS咨询委员会）讨论并探讨了从发病率控制转变为消除传播的转变中的这一需求。当前，WASH的评估标准主要集中在两个方面收集的数据上：获得新鲜饮用水和安装适当的厕所，这些厕所忽略了环境传播的其他重要因素，例如，人类水接触行为和Schistosom的水生生物学。

With the above in mind, in thisstudy我们的目的是对这些疾病特有的两个领域的血吸虫病和STH流行病学进行详细的情境分析，包括对WASH的评估：Barombi MBO和Barombi Kotto喀麦隆的Barombi Kotto Crater湖泊。

这两个湖泊是重要的torical and parasitological importance, being exemplar locations where seminal integrated control of schistosomiasis was attempted in the 1970s, using a combination of preventive chemotherapy and snail control via mollusciciding.

Subsequently, with the wide-scale administration of praziquantel, treatment has been provided annually to schoolchildren for the past decade. A contemporary situational assessment is therefore important. Our study is one of very few detailed investigations of multiple helminths, using multiple diagnostic techniques, in co-endemic settings, following more than ten years of preventive chemotherapy.

It is highly likely that this WASH infrastructure has been a considerable driver in reducing the helminths to such a low prevalence.

从这一集成的监视中，出现了最有趣的图片。我们发现患病率很低Schistosoma haematobium和Barombi MBO的钩虫。我们没有发现肠道血吸虫病或其他STH。在水生栖息地方面，我们发现了两个蜗牛宿主的数量很少Schistosoma haematobium,Bulinus摄影和Bulinus truncatus每个都具有变量变速箱能力。

在Barombi MBO上，已经安装了一个广泛的乡村水基础设施，从受保护的弹簧和重力过滤器到公共支架台管。尽管我们永远不会明确地知道，但考虑到其以前的历史流行性，这种洗涤基础设施很有可能是将蠕虫降低到如此低的流行率的相当低的驱动力。现在，有一个前所未有的机会来推动该社区消除血吸虫病。

在Barombi Kotto，我们发现了截然不同的人类旋转 - 寄生虫动力学，具有较高的蠕虫患病率和强度和不同的宿主蜗牛分布。虽然有些家庭有厕所，但洗涤基础设施通常很差。

虽然有些家庭有厕所，但洗涤基础设施通常很差。

This very different population and water access dynamic highlights a critical issue for consideration: given the history of mass drug administration, to push this site towards disease elimination, additional environmental and WASH infrastructure will likely be required, and tailored with local behavioral-related activities.

我们的研究设定了现场，以进一步评估环境因素，并为制定针对中断传播的加强控制策略提供重要信息。国家NTD控制计划最终将需要进步，而不是预防性化疗，以适应包括WASH在内的疾病和人类传播动态。

Environmental strategies will need to be tailored to local differences, as a key enhancement to continuation of large-scale mass drug administration. To do this well, more engagement with critical aspects within the WASH sector is needed.