童年肥胖

会议的一个主要重点是在干预措施，以防止或减少儿童肥胖，以及研究揭示导致它的潜在机制。

会议的一个主要重点是在干预措施，以防止或减少儿童肥胖，以及研究揭示导致它的潜在机制。AntjeKörner.讨论了在调查原因时考虑到环境，（EPI）遗传和预处理因素的重要性;例如，高母体BMI之间存在关联，并且出生在胎龄，以及快餐网点和高青少年BMI之间的地理重叠。一个有趣的研究质量队列，呈现梅兰妮亨德森那found changes across the lifespan in the gut microbiome of obese children compared to normal weight, such as abundance of roseburia in the former.Odysseas Androutsos提出了这一发现Toybox study- 全球幼儿园老年人，基于家庭的干预，以防止儿童肥胖。一个有趣的结果是，地区内的社会经济群体较低的社会经济群体表现出更高的肥胖/超重儿童的流行，并且发现在研究的南部地区聚集了不健康的行为。然而，干预措施在增加耗水量，减少甜食，并在一周内改善身体活动。

oncofertility.

Teresa Woodruffpresented an excellent plenary lecture on the technological advances to overcome the detrimental effects of cancer treatments on fertility. This includes the development of微流体装置to mimic the behaviour of organs and model the 28-day human menstrual cycle, and'卵巢纸'改善了卵巢卵泡存活。

SGA.

许多会谈解决与出生的小于胎龄（SGA）相关的因素。Francis de Zegher指出，在这种情况下，母乳喂养优于配方喂养，以促进皮下脂肪发生，从而为脂肪储存产生更多空间。审议讨论是否审议 - 以及在什么年龄 - 开始增长激素（GH）治疗。Anders Juul提到了一项北欧研究，表明，3中的否则响应者对治疗不良，虽然其建议在2到4岁之间开始治疗“真实世界”的证据表明，事实上，起始的平均年龄是8年。Anita Hokken-Koelegacovered the long-term safety and metabolic outcomes of GH treatment, noting that 6.5 years post treatment cessation there was no negative impact on their metabolic profile (compared to untreated SGA short controls) but they did exhibit lower lean body mass.大卫达格进一步指出，2型糖尿病和代谢综合征的危险因素在未处理和先前治疗的SGA儿童之间相当，但补充说快速追赶生长与肥胖和早期的青春期有关。

Type 1 diabetes mellitus

This interesting and engaging meeting not only showcased some key advances in the field of paediatric endocrinology, but also highlighted important areas benefiting from collaborative efforts and cross-disciplinary approaches to provide novel interventions and therapeutic options in the future.

Olga Kordonouricovered a range of modern technologies to optimise diabetes care in those with type 1 diabetes mellitus (T1DM), such as flash glucose monitoring and the hybrid closed-loop system.Anette-Gabriele Zieglerdescribed a genetic risk score that can identify a 10-fold risk of T1DM in the general population.Tadej Battelino.瑞典注册表研究提出了一些有趣的调查结果，揭示了具有T1DM的年轻成年人的死亡率和心血管疾病的过度死亡率和心血管疾病;女性的心血管疾病的风险特别较大。事实上，在很小的年轻（10岁以下）中，有一个17-year difference in life expectancy在正常的孩子和T1DM的人之间。这种降低了预期寿命和转向较年轻的年龄 - 除了增加的流行过程 - 意味着新的治疗方法是高度追捧的。斯蒂芬诞生described a number of pancreatic replacement strategies. This includes a pancreas transplant; though this results in increased efficacy, there is a limited number of donors and it’s a major surgery. Islet transplant is less invasive than a pancreas transplant, but there are very few centres able to do it. As this occurs post total pancreatectomy, the islets are often transplanted to the liver; however, as this is not the optimal environment there is a gradual loss of islets post transplantation. Current strategies showing potential include a生物胰腺and胰岛细胞的微胶囊。The latter has been trialled in a German non-human primate centre, and was在人类中进行测试for almost 1 year; promisingly, this case showed improved glycaemic control and the islets survived without the need for immunosupression.帕特里克科尔蒙特还通过治疗α细胞来讨论再生人β细胞的方法GABA;发现这是逆转几轮化学诱导的糖尿病。如果这些新的β细胞可以存活被杀死，因此仍然是仍然可以看出，希望再生率足以补偿损失率。人类的试验研究目前正在进行中。

This interesting and engaging meeting not only showcased some key advances in the field of paediatric endocrinology, but also highlighted important areas benefiting from collaborative efforts and cross-disciplinary approaches to provide novel interventions and therapeutic options in the future.